Accession Number : ADA138679

Title :   The Effect of Chemotherapeutic Agents on Immune Reactions.

Descriptive Note : Annual rept. Sep 81-Aug 82,


Personal Author(s) : Ghaffar,A

PDF Url : ADA138679

Report Date : Aug 1982

Pagination or Media Count : 33

Abstract : Immunotoxic effects of WR 99,210, WR 122,455, and WR-228,258 were tested in the animal model for the screening. WR 99,210 caused a significant enhancement in the phagocytic function (alpha value), and severe depression in the antibody PFC response when given before antigen, and reduction in the liver and spleen sizes. WR 122,455 and WR 228,258 had similar effects, although with somewhat less severity. Thus, the reduction in the PFC responses and reduction in splenic and hepatic sizes was less pronounced. WR 122,455 was relatively more effective in stimulating the phagocytic function whereas WR 228,258 caused no significant alteration in the phagocytic function. None of the agents seemed to alter significantly the delayed hypersensitivity reaction. In addition, T and B lymphocyte contents in the peripheral blood of human volunteers treated with WR 171,669 (single dose of 750 to 2000 mg) were enumerated. These studies evaluated 24 individuals before and 2 days after the treatment: half of these volunteers received various doses of the drug and the other half received a placebo. No significant differences were noticed in the proportions of T and B cells in the peripheral blood of these volunteers when placebo and drug-treated groups on Day 0 and Day 2 (pre- and post-treatment) samples were compared.

Descriptors :   *Chemotherapeutic agents, *Immunity, Physiological effects, Spleen, Liver, Reduction, Lymphocytes, Dosage, Toxicity, Sizes(Dimensions)

Subject Categories : Medicine and Medical Research

Distribution Statement : APPROVED FOR PUBLIC RELEASE