Accession Number : ADA138726

Title :   Mechanisms Involved in Immunity to Malarial Parasites.

Descriptive Note : Final rept. Sep 77-Jun 79,

Corporate Author : GLASGOW UNIV (SCOTLAND)

Personal Author(s) : Phillips,R S

PDF Url : ADA138726

Report Date : Jul 1980

Pagination or Media Count : 68

Abstract : Part I - Immunity to Plasmodium falciparum in Man. The procedure for the continuous cultivation of the erythrocytic stages of P. falciparum following the method of Trager and Jensen (1976) has been established in our laboratory. Nineteen sera from non-immunes showed varying abilities to support growth of P. falciparum in microcultures indicating the necessity for adequate controls in testing human immune sera for antiparasitic activity. Infected blood from 82 patients was cryopreserved. Thirty-four patients returned after recovery and gave usable serum samples to test for antiparasitic activity. Part II - Immunity to rodent malaria parasites. Fractionation of immune spleen cells into T-cell and B-cell enriched populations and treatment of these populations with anti-T-cell antisera before transfer into irradiated naive recipients confirmed a role for both T- and B-cells in immunity to P. chabaudi. Infection of mice with Mycobacterium lepraemurium, murine, leprosy, gave the mice considerable resistance to a later infection with Babesia microti and some resistance to P. chabaudi.

Descriptors :   *Immunity, *Malaria, *Parasites, *Plasmodium, *Plasmodium falciparum, Rodents, Mice, Irradiation, Spleen, Removal, Immune serums

Subject Categories : Medicine and Medical Research

Distribution Statement : APPROVED FOR PUBLIC RELEASE