Accession Number : ADA138746

Title :   Anticholinesterase Effects on Number and Function of Brain Muscarinic Receptors and Central Cholinergic Activity: Drug Intervention.

Descriptive Note : Interim annual scientific rept. no. 1, 1 Aug 82-31 Jul 83,

Corporate Author : ISTITUTO DI RICERCHE FARMACOLOGICHE MARIO NEGRI MILAN (ITALY)

Personal Author(s) : Ladinsky,H

PDF Url : ADA138746

Report Date : 30 Sep 1983

Pagination or Media Count : 28

Abstract : This study endeavors to elucidate the acute mechanisms adapted by the body to reduce cholinergic in order to fend off the toxic effects of anticholinesterase poisons. The effect of DDVP on rat brain acetylcholine content was characterized. The drug increased ACh in hemispheric structures (striatum, hippocampus, cortex) but not in cerebellum or midbrain-hindbrain. Pretreatments with atropine or reserpine only partially prevented the DDVP-induced increases. These and other experiments suggest that DDVP acted through a feedback mechanism secondarily to muscarinic receptor stimulation by the protected synaptic ACh. The feedback activation mediated by a monoamine leads to intraneuronal storage of ACh. Another fraction, perhaps smaller, accumulates extraneuronally and likely is responsible for the toxicity.

Descriptors :   *Acetylcholine, *Cholinesterase inhibitors, *Muscarine, *Organic phosphorus compounds, Brain, Chemoreceptors, Central nervous system, Stimulation(Physiology), Toxicity, Rats, Atropine, Reserpine

Subject Categories : Toxicology
      Pharmacology

Distribution Statement : APPROVED FOR PUBLIC RELEASE