Accession Number : ADA138852

Title :   Effect of Anti-Parasite Chemotherapeutic Agents on Immune Reactions.

Descriptive Note : Annual rept. no. 2, Sep 79-Aug 80,


Personal Author(s) : Ghaffar,A

PDF Url : ADA138852

Report Date : Aug 1980

Pagination or Media Count : 32

Abstract : Immunotoxic effects of four agents, WR 171669, WR 142490, WR 172435 and WR 180409, were studied. WR 171669, at maximal sublethal dose, caused a slight increase in the antibody plaque-forming cell (PFC) response, and marginal suppression in the delayed hypersensitivity (DH) reaction and in vivo phagocytic function. WR 142490 caused slight reduction in the splenic cell content at the higher dose given before or after the antigen. It did not significantly affect antibody PFC responses at any dosage or timing. The DH reaction was suppressed by this agent given before or after the antigen, but the statistical significance was demonstrable only in the group receiving a high dose of the drug before the antigen. WR 172435 caused a significant reduction in IgG response in only one instance: in mice treated with 10 mg/kg of the drug one day after antigen. WR 180409, at the higher dose, caused a small but significant reduction in the cellularity of the spleen. Given at the high dose before antigen it caused significant suppression of the IgG response but when given after the antigen it caused a slight augmentation. DH reactions were not at all altered by this drug. None of these drugs had a dramatic effect on any of the immune parameters measured.

Descriptors :   *Antiparasitic drugs, *Chemotherapeutic agents, *Immunology, *Toxicity, Immunity, Antibodies, Hypersensitivity, Phagocytes, Immunoglobulins, Antigens, Cells(Biology), Spleen, Dosage, Mice

Subject Categories : Toxicology

Distribution Statement : APPROVED FOR PUBLIC RELEASE