Accession Number : ADA138936

Title :   S-Esters of Thiohydroximic Acid Esters - A Novel Class of Cholinesterase Reactivators.

Descriptive Note : Annual rept. Oct 79-Oct 80,


Personal Author(s) : Kenley,R A ; Howd,R A ; Mosher,C W ; Winterle,J S

PDF Url : ADA138936

Report Date : 05 Jan 1981

Pagination or Media Count : 57

Abstract : A series of S-esters of thiohydroximic acid esters, given by the general formula RC(:O)C(:NOH)S(CH2)nNR2'HCl, where R = CH3; CH3OC6H4, C6H4, NO2C6H4; n = 2,3', R' = CH3, C2H5, or i-C3H7 have been prepared. The compounds were characterized with respect to acidity, nucleophilicity, and kinetics of reactivation of diisopropyl phosphoryl-acetylcholinesterase. The compounds were moderately active in reactivation of the enzyme, and activity is highly dependent on reactivator structure.

Descriptors :   *Esters, *Acetylcholinesterase, *Reactivities, Oximes, Fluorine compounds, Acids, Nucleophilic reactions, Reaction kinetics, Chemical dissociation, Acetates, Nitro radicals, Phenyl radicals, Displacement reactions, Methyl radicals, Bromides, Chlorides, Cholinesterase inhibitors, Intoxication, Antidotes, Membranes(Biology), Penetration, Molecular structure

Subject Categories : Biochemistry
      Organic Chemistry

Distribution Statement : APPROVED FOR PUBLIC RELEASE