Accession Number : ADA139087

Title :   Mechanisms of Protective Immunogenicity of Microbial Vaccines of Military Medical Significance.

Descriptive Note : Annual summary rept. Dec 80-Dec 81,


Personal Author(s) : Ascher,M S ; Berman,M A

PDF Url : ADA139087

Report Date : Jan 1982

Pagination or Media Count : 30

Abstract : Initial clinical studies of Phase I Q fever vaccine (IND no. 610) have been undertaken this year in 18 volunteers at two dose levels. Local reactions to vaccine were minimal and without abscess or granuloma formation. Immunologic results show consistent antibody responses and variable lymphocyte transformation responses to Q fever antigens. Dermal granulomatous skin reactions seen to Q fever vaccine antigens in immune guinea pigs have been analyzed for their immunologic basis. New information has been obtained on the interrelations between antigens of C. burnetii and their relative contributions to granuloma formulation. FIAX immunofluorescent assay procedures were used for serodiagnosis of Q fever and Legionnaire's disease and for detection of antigens from C. burnetii. Hybridoma antibodies were prepared in mice to Q fever antigens and assayed by FIAX and a new radioimmunoassay technique.

Descriptors :   *Vaccines, *Q fever, *Legionnaires disease, *Coxiella burnetii, Immunology, Humans, Lymphocytes, Dosage, Antibodies, Response(Biology), Antigens, Radioimmunoassay, Serology, Serodiagnosis

Subject Categories : Medicine and Medical Research

Distribution Statement : APPROVED FOR PUBLIC RELEASE