Accession Number : ADA139536

Title :   Genetic and Molecular Studies of the Phlebotomus Fever Group of Viruses.

Descriptive Note : Annual rept. 1 Sep 82-31 Aug 83,


Personal Author(s) : Bishop,D H L

PDF Url : ADA139536

Report Date : Aug 1983

Pagination or Media Count : 19

Abstract : Studies supported by this contract have reported the characterization of the structural components of several Phlebotomus fever serogroup viruses (viral polypeptides and RNA species). The viruses studied include Punta Toro (PT), Karimabad (KAR), Chagres (CHG), Sandfly fever Sicilian (SFS Tesh and Sabin isolates). Sandfly Fever Naples (SFN), Rift Valley Fever (RVF), Phlebotomus 3 virus (PHL 3), Icoraci (ICO) and Buenaventura (BUI) viruses. With the demonstration of a tripartite RNA genome, genetic analyses were also undertaken in order to determine the coding strategies of the 3 RNA species and determine if recombinant viruses could be obtained and used for vaccine purposes. The coding strategy of the 3 RNA species are being investigated with the goal of characterizing the epitopes on viral antigens that elicit and interact with neutralizing antigens. Such goals are being realized by cloning and sequencing studies.

Descriptors :   *Sandfly fever virus infection, *Vaccines, Genetics, Molecules, Ribonucleic acids, Antigens, Coding

Subject Categories : Medicine and Medical Research

Distribution Statement : APPROVED FOR PUBLIC RELEASE