Accession Number : ADA140054

Title :   Studies of Altered Response to Infection Induced by Thermal Injury.

Descriptive Note : Annual progress rept. 1 Jan-31 Dec 79,

Corporate Author : CALIFORNIA UNIV SAN FRANCISCO

Personal Author(s) : Miller,C L

PDF Url : ADA140054

Report Date : Jan 1980

Pagination or Media Count : 25

Abstract : In summary, our laboratory has substantial data indicating that a monocyte defect does appear in severely burned patients who will eventually develop severe or fatal septicemia. This loss of patient monocyte function appears to correlate with a development of excessive T suppressor cells and mitogen hyporesponsiveness. Our preliminary data from a murine system seem to support that unbalancing of the immune network toward too much regulation (ie, increased T suppressor cells) is preceded by, and is probably a result of, loss of monocyte function.

Descriptors :   *Burns(Injuries), *Infectious diseases, *Radiation effects, *Immunity, Thermal radiation, Response(Biology), Septicemia, Leukocytes, Dysfunction, Preventive medicine, Inflammation, Monocytes, Patients, Humans, Mice, Bone marrow, Thymus

Subject Categories : Medicine and Medical Research

Distribution Statement : APPROVED FOR PUBLIC RELEASE