Accession Number : ADA140107

Title :   Studies of Altered Response to Infection Induced by Thermal Injury.

Descriptive Note : Annual progress rept. 1 Jan 81-15 Mar 82,

Corporate Author : CALIFORNIA UNIV SAN FRANCISCO

Personal Author(s) : Miller,C L

PDF Url : ADA140107

Report Date : Mar 1982

Pagination or Media Count : 33

Abstract : This report describes the results of this year's experiments to reduce the post-burn incidence of fatal sepsis by (1) rapidly identifying and segregating those individuals that are at greatest risk of sepsis; (2) delineating the nature of the burn-induced immune defect; and (3) characterizing those mechanisms by which thermal injury causes immune aberrations. Understanding of these mechanisms may allow development of far forward prophylactic measures which could prevent thermal injury from inducing immune defects. Experimental data derived from our patient studies have allowed us to develop assays for detecting early immune anomalies and to delineate the cell type(s) involved in these aberrations. Our guinea pig model has been primarily utilized to characterize the mechanisms by which thermal injury causes the development of immune defects.

Descriptors :   *Burns(Injuries), *Infectious diseases, *Radiation effects, *Immunity, Thermal radiation, Response(Biology), Septicemia, Patients, Dysfunction, Leukocytes, Antigens, Bone marrow, Thymus, Monocytes, Trauma, Antibodies, Patients

Subject Categories : Medicine and Medical Research

Distribution Statement : APPROVED FOR PUBLIC RELEASE