Accession Number : ADA140121

Title :   Distribution and Characterization of Antigens Found in Subcellular Fractions of African Trypanosomes.

Descriptive Note : Annual rept. 20 Aug 80-21 Aug 81,


Personal Author(s) : McLaughlin,J

PDF Url : ADA140121

Report Date : Aug 1981

Pagination or Media Count : 52

Abstract : This report describes the experiments to determine the subcellular localization of antigens in the African trypanosome Trypanosoma rhodesiense. Most of the antigenic components are associated with the surface membrane and flagellar pocket membrane. One prominent lysosomal antigen is present. At least 5 of the flagellar pocket antigens are glycoprotein and two of these display identical electrophoretic mobilities with surface membrane glycoproteins. Preliminary experiments show the surface membrane and lysosomal fractions to be the most protective against challenge infection with T. rhodesiense. The lysosomal flagellar pocket membrane fractions were also protective. Neither the promitochondrial or glycosomal fraction appeared particularly antigenic or to have protective potential.

Descriptors :   *Trypanosoma, *Immunology, *Africa, Antigens, Electrophoresis, Enzymes, Glycoproteins, Membranes(Biology)

Subject Categories : Medicine and Medical Research

Distribution Statement : APPROVED FOR PUBLIC RELEASE