Accession Number : ADA140132

Title :   Studies of Altered Response to Infection Induced by Thermal Injury.

Descriptive Note : Annual progress rept. 1 Jan-31 Dec 80,


Personal Author(s) : Miller,C L

PDF Url : ADA140132

Report Date : Jan 1981

Pagination or Media Count : 27

Abstract : In summary, our laboratory has produced substantial data indicating that M0 dysfunction does appear in those severely burned patient who will eventually develop severe or fatal septicemia. This M0 dysfunction is characterized by a loss of M0 PA production and a rise in M0 TF generation. Loss of patient M0 PA function appears to correlate to a development of T suppressor cels and mitogen hyporesponsiveness. M0 PA appears to be a property of the facilitory M0 subset and to be a marker for facilitory M0 functionality. The data from our human systems also suggest that once excessive T suppressor cells are activated after thermal injury, they can then further disrupt vital facilitory M0 functions. our data from the murine system supports the concept that unbalancing of the immune network toward too much regulation (ie, unbalancing suppressor T cells) is preceeded by and probably a result of depressed monocyte facilitory immune function.

Descriptors :   *Burns(Injuries), Patients, Septicemia, Immunity, Response(Biology), Lymphocytes, Dysfunction

Subject Categories : Medicine and Medical Research

Distribution Statement : APPROVED FOR PUBLIC RELEASE