Accession Number : ADA140135

Title :   Cardio-Pulmonary Response to Shock.

Descriptive Note : Annual progress rept. 1 Sep 78-31 Dec 79,

Corporate Author : HARVARD MEDICAL SCHOOL BOSTON MA

Personal Author(s) : Hechtman,H B

PDF Url : ADA140135

Report Date : Dec 1979

Pagination or Media Count : 15

Abstract : Pressure breathing and particularly end-expiratory pressure will induce the pulmonary production of prostaglandins (PG). These PGs regulate cardiac contractility and the release of plasmin mediated fibrinolytic activity. A high molecular weight protein has been tentatively identified as the circulating negative inotropic agent whose production is stimulated by PG synthesis during end-expiratory pressure. The large amount of prostacyclin (PGI2) secreted by the lungs in response to surgery may protect against microaggregate entrapment and damage of the lungs. PGI2 infusion is effective therapy for experimental pulmonary embolism.

Descriptors :   *Prostaglandin, *Shock(Pathology), Pulmonary function, Blood circulation, Serotonin, Trauma, Surgery, Stimulation(Physiology), Fibrinolysis, Response(Biology), Plasmin, Metabolism, Lung

Subject Categories : Biochemistry
      Anatomy and Physiology

Distribution Statement : APPROVED FOR PUBLIC RELEASE