Accession Number : ADA140255

Title :   Acute Infectious Disease,

Corporate Author : ARMY MEDICAL RESEARCH INST OF INFECTIOUS DISEASES FORT DETRICK MD

Personal Author(s) : Beisel,W R

PDF Url : ADA140255

Report Date : 23 Mar 1984

Pagination or Media Count : 70

Abstract : The development of acute generalized infectious illnesses and serious inflammatory reactions is accompanied by the occurrence of a large number of interrelated host defensive measures. These constitute the generalized acute-phase response to infection, inflammatory states, or complex trauma. These responses include the development of fever and hypermetabolism, the production of a leukocytic response, the accelerated proteolysis of skeletal muscle, the generation of free amino acids from body somatic protein catabolism, the production of a number of hormones, the synthesis by the liver of acute-phase reactant proteins and of various intracellular enzymes, the acceleration within the liver of gluconeogenesis and lipogenesis with a relative suppression of ketogenesis, the redistribution and/or sequestration of various trace elements, and, importantly, the stimulation of immune system activity. These components of the acute-phase generalized, nonspecific metabolic response to acute infection are triggered by the release from activated monocytes and tissue macrophages of endogenous mediators which are currently grouped under the term Interleukin-l.

Descriptors :   *Infectious diseases, *Immunity, Nutrition, Inflammation, Resistance(Biology), Hosts(Biology), Trauma, Fevers, Hypermetabolism, Leukocytes, Response(Biology), Proteins, Protein metabolism, Carbohydrates, Amino acids, Catabolism, Hormones, Minerals, Vitamins, Glycolysis, Lipids, Stimulation(Physiology), Anorexia, Shock(Pathology)

Subject Categories : Medicine and Medical Research

Distribution Statement : APPROVED FOR PUBLIC RELEASE