Accession Number : ADA140331

Title :   Isolation and Characterization of Erythrocyte and Parasite Membranes from Rhesus Red Cells Infected with P. knowlesi.

Descriptive Note : Final rept. Jun 74-Jul 81,

Corporate Author : TUFTS-NEW ENGLAND MEDICAL CENTER BOSTON MA

Personal Author(s) : Wallach,D F H

PDF Url : ADA140331

Report Date : Jul 1983

Pagination or Media Count : 10

Abstract : Erythrocytic forms of Plasmodia synthesize glycoproteins that become exported from the parasite and its vacuole to be inserted into the host cell membrane. The best characterized protein of this category is an Mr 74 000, pI 4.8 glycoprotein, synthesized by plasmodium knowlesi, PkGP74, has immunogenic glycopeptide exposed at the external host cell membrane surface of erythrocytes infected with plasmodium knowlesi schizonts, presence of antibodies against PkGP74, correlate with immune protection of monkeys against plasmodium knowlesi. PkGP74, shares peptide and immunogenic moieties with a similar protein located in the membranes of erythrocytes infected with plasmodium falciparum.

Descriptors :   *Erythrocytes, *Plasmodium, *Immunity, *Plasmodium knowlesi, *Plasmodium falciparum, Isolation, Immunology, Membranes(Biology), Immunochemistry, Proteins, Antibodies, Antigens, Biosynthesis

Subject Categories : Medicine and Medical Research

Distribution Statement : APPROVED FOR PUBLIC RELEASE