Accession Number : ADA140400

Title :   The Effect of an Electrical Left Ventricular Assist Device on Red Blood Cell and Platelet Survival in the Cow.

Descriptive Note : Technical rept.,

Corporate Author : BOSTON UNIV MA SCHOOL OF MEDICINE

Personal Author(s) : Melaragno,A J ; Vecchione,J J ; Katchis,R J ; Abdu,W A ; Ouellet,R P

PDF Url : ADA140400

Report Date : 23 Apr 1982

Pagination or Media Count : 22

Abstract : Blood volume measurements were made in cows after infusion of human 125 iodine albumin and autologous 51 chromium-labeled red blood cells. Repeated intravenous infusions of iodinated human albumin did not appear to isosensitize the cows. When the cow red blood cells were incubated at 37 C after labeling with 51 chromium, there was elution of the 51 chromium, and the 51 chromium T 50 values were 45 hours in both healthy cows and cows with LVAD's. Measurements also were made in the cow platelets labeled with 51 chromium or 111 Indium-oxine. The platelets labeled with 51 chromium had T 50 values of 4 days, and platelets labeled with 111 Indium-oxine had T 50 values of 0.9 to 2.7 days. 51 chromium-labeled platelets had similar T 50 values in healthy cows and cows with LVAD's. Bovine platelets isolated from units of blood using serial differential centrifugation were labeled with 51 chromium or with 111 Indium-oxine, and after infusion in healthy cows and cows with LVAD's measurements were made of platelet circulation and distribution. The disappearance of platelet radioactivity from the blood was linear with time, and the platelet lifespan was 6-10 days. The presence of an LVAD did not affect initial recovery or lifespan of cow platelets.

Descriptors :   *Erythrocytes, *Blood platelets, Bovines, Blood volume, Measurement, Labeled substances, Radioactive isotopes, Chromium, Indium, Iodine, Radioactivity, Reduction, Recovery

Subject Categories : Medicine and Medical Research

Distribution Statement : APPROVED FOR PUBLIC RELEASE