Accession Number : ADA140406

Title :   A Comparison of Methods Used for Determination of the 100% Survival of Preserved Red Blood Cells.

Descriptive Note : Technical rept.,

Corporate Author : BOSTON UNIV MA SCHOOL OF MEDICINE

Personal Author(s) : Valeri,C R ; Pivacek,L E ; Ouellet,R ; Gray,A

PDF Url : ADA140406

Report Date : 13 Jul 1982

Pagination or Media Count : 53

Abstract : Three methods were evaluated to determine which gave the most accurate 100% survival value from which to estimate the 24-hour posttransfusion survival of 51Cr-labeled preserved red blood cells: (1) indirect measurement of the recipient's red blood cell volume using 125I albumin and the total body area nomogram; and (3) extrapolation of the radioactivity associated with the red blood cells in the recipient's circulation after the transfusion. When less than 20% of the transfused survival values of between 80-100%, the three methods have comparable results. Data indicated that when nonviable red blood cells are rapidly removed from the circulation immediately after transfusion, the extrapolation method gives an underestimation of the 100% survival value, resulting in an overestimation of the 24-hour posttransfusion survival value.

Descriptors :   *Erythrocytes, *Blood preservation, Determination, Test methods, Comparison, Accuracy, Survival(General), Labeled substances, Blood volume, Value, Radioactivity, Extrapolation, Radioactive isotopes, Chromium, Iodine

Subject Categories : Anatomy and Physiology

Distribution Statement : APPROVED FOR PUBLIC RELEASE