Accession Number : ADA140432

Title :   The Effect of Hypothermia on Hemostasis in the Baboon.

Descriptive Note : Technical rept.,


Personal Author(s) : Melaragno,A J ; Dennis,R C ; Feingold,H ; Doty,A ; Collins,L

PDF Url : ADA140432

Report Date : 12 Aug 1983

Pagination or Media Count : 34

Abstract : The effect of hypothermia on platelet number and function and blood coagulation was studied in baboons cooled to a body temperature of 32 C. During the reduction in body temperature to 32 C, platelet counts were normal and platelet function was normal when assessed by platelet aggregation patterns, platelet dense body content, and release of platelet beta thromboglobulin. Hypothermia to 32 C was associated with a prolonged bleeding time, which was corrected by rewarming to 37 C, but was not associated with increased arterial levels of theromboxane A2 or prostacyclin. A 10-20% prolongation of the prothrombin time and activated partial thromboplastin time and a reduction in plasma fibrinogen levels were observed both during hypothermia and after rewarming of the baboon. The prolongation of the clotting tests may have been due to dilution of the plasma proteins as a result of the withdrawal of blood and the infusion of large volumes of sodium chloride solution during the study.

Descriptors :   *Hypothermia, *Blood circulation, *Blood platelets, *Blood coagulation, *Baboons, Blood counts, Thromboplastin, Globulins, Hemorrhage, Time, Patterns, Heat treatment, Fibrinogen, Infusions, Sodium chloride, Solutions(Mixtures)

Subject Categories : Medicine and Medical Research

Distribution Statement : APPROVED FOR PUBLIC RELEASE