Accession Number : ADA140506

Title :   Neurotransmitter Amines in Hemorrhagic Shock.

Descriptive Note : Final rept. 1 Aug 79-31 Mar 83,


Personal Author(s) : Proctor,H J ; Cairns,C ; Fillipo,D ; Palladino,G W ; Rosner,M J

PDF Url : ADA140506

Report Date : 02 Mar 1984

Pagination or Media Count : 83

Abstract : Intravenous infusion of ATP-MgCl as part of resuscitation from hemorrhagic shock gives transiently better high-energy phosphate levels in the liver with no apparent benefit to the brain. Investigations into combinations of hemorrhagic shock and hypoxia in conjunction with hypothermia show that hypothermia is beneficial during the period of hypoxic hypotension, but continued hypothermia after resuscitation serves no useful purpose. High-frequency ventilation as administered using the principle of oscillation of an insufflated air stream into the trachea provides equal oxygenation at lower airway pressures when compared to jet ventilation and conventional respirator ventilation. Brain high-energy phosphate levels appear to be improved after hypoxic hypotension when resuscitation includes nifedipine. This is most likely due to the vasodilation effect of nifedipine as opposed to an intraneuronal mechanism. Perfluorochemical Fluosol-43 functions adequately as a volume expander and oxygen transport medium when utilized to resuscitate animals from hypoxix hypotension. Exchange transfusions of pregnant ewes utilizing either balanced salt solution or Fluosol demonstrate a clear-cut superiority of Fluosol in terms of the fetal oxygenation as assessed by infrared spectrophotometry.

Descriptors :   *Amines, *Hemorrhagic shock, *Nerve transmission, Hyperthermia, Hypoxia, Respiration, Brain, Metabolism, Phosphates, Level(Quantity)

Subject Categories : Anatomy and Physiology

Distribution Statement : APPROVED FOR PUBLIC RELEASE