Accession Number : ADA140524

Title :   Effect of Red Blood Cell Storage on Cardiac Performance. Improved Myocardial Oxygen Delivery and Function during Constant Flow Coronary Perfusion with Low Oxy-Hemoglobin Affinity Human Red Blood Cells in Normothermic and Hypothermic Rabbit Hearts.

Descriptive Note : Technical rept.,


Personal Author(s) : Apstein,C S ; Dennis,R C ; Briggs,L ; Vogel,W M ; Frazer,J

PDF Url : ADA140524

Report Date : 01 Feb 1983

Pagination or Media Count : 73

Abstract : Red blood cell storage can result in depression of erythrocyte 2,3,-diphosphoglycerate (DPG) levels, thereby increase oxy-hemoglobin affinity and potentially decrease capillary-to-tissue oxygen transport. We assessed the metabolic and functional effects which resulted from red blood cell storage by using an isolated rabbit heart preparation with an isovolumic left ventricular balloon. Coronary flow was held constant to simulate the physiology of coronary atherosclerosis and other conditions of limited coronary vasodilator reserve where coronary flow cannot increase in response to an increase in myocardial oxygen demand. Myocardial function and metabolism were measured under basal conditions and during isoproterenol stress at 37 and 30 C. The coronary arterial perfusate was alternated between red blood cell suspensions composed of either high or low oxy-hemoglobin affinity red blood cells.

Descriptors :   *Erythrocytes, *Blood preservation, Myocardium, Oxygen, Delivery, Functions, Heart, Rabbits, Heart function tests, Metabolism, Hemoglobin

Subject Categories : Medicine and Medical Research

Distribution Statement : APPROVED FOR PUBLIC RELEASE