Accession Number : ADA140669

Title :   Genetic and Molecular Studies of the Phlebotomus Fever Group of Viruses.

Descriptive Note : Annual rept. 1 Sep 79-31 Aug 80,

Corporate Author : ALABAMA UNIV IN BIRMINGHAM

Personal Author(s) : Bishop,D H L

PDF Url : ADA140669

Report Date : Aug 1980

Pagination or Media Count : 27

Abstract : During this reporting period we have continued studies which have led to characterizing the structural components of several Phlebotomus fever serogroup viruses (viral polypeptides and, or RNA species). The viruses studied include Punta Toro (PT), Karimabad (KAR), Charges (CHG), Sandfly fever Sicilian (SFS Tesh and Sabin isolates). Sandfly fever Naples (SFN), Rift Valley fever (RVF), Phlebotomus 3 virus (Ph1 3), Icoraci (ICO) and Buenaventura (BUE) viruses. In summary, the evidence has shown that the viruses have 3 virion RNA species, which are comparable in number to those of other members of the family, but different in size for the S RNA. The studies have also shown that, although the N polypeptides of Phlebotomus fever group viruses are similar in size to those of bunyaviruses, the glycoproteins are quite different. Thus both the RNA and polypeptide analyses have shown that the members of serogroup are distinct from members of the Bunyavirus genus. This evidence, developed for the Phlebotomus fever serogroup viruses, plus the serological data and evidence developed from bunyaviruses and nairoviruses has been the basis for the proposal of the formation of new genera of viruses in the family Bunyaviridae (Phlebovirus and Nairovirus genera).

Descriptors :   *Sandfly fever virus infection, *Vaccines, Genetics, Molecular biology, Antigens, Ribonucleic acids, Fingerprints, Molecular structure, Peptides, Coding, Glycoproteins

Subject Categories : Medicine and Medical Research

Distribution Statement : APPROVED FOR PUBLIC RELEASE