Accession Number : ADA140715
Title : Mechanisms of Protective Immunogenicity of Microbial Vaccines of Military Medical Significance.
Descriptive Note : Annual summary rept. Sep-Dec 80,
Corporate Author : CALIFORNIA UNIV IRVINE DEPT OF MEDICINE
Personal Author(s) : Ascher,M S
PDF Url : ADA140715
Report Date : 30 Jan 1981
Pagination or Media Count : 46
Abstract : Clinical studies of Q fever vaccine have been undertaken with screening of volunteers for humoral and cellular immune reactivity to specific Q fever antigens. A rapid and simplified immunofluorescent procedure has been developed for serodiagnosis of Q fever and tularemia suitable for field use. Excellent correlation exists between the results of this procedure and standard complement fixation testing for diagnosis of Q fever. Lot-to-lot variability of phase I Q fever vaccine has been assessed by in vitro lymphocyte transformation testing of immune guinea pigs. There is a consistent response between lots of vaccine by this technique and no evidence of endotoxin contamination in the vaccine. Delayed hypersensitivity skin testing of guinea pigs with Q fever antigen has revealed granulomatous changes with giant cell prominence. The immunologic basis of the granulomatous response is under analysis.
Descriptors : *Vaccines, *Q fever, Immunology, Antigens, Serodiagnosis, Fluorescence, Immunity, Response(Biology), Guinea pigs, Immunoassay
Subject Categories : Medicine and Medical Research
Distribution Statement : APPROVED FOR PUBLIC RELEASE