Accession Number : ADA140715

Title :   Mechanisms of Protective Immunogenicity of Microbial Vaccines of Military Medical Significance.

Descriptive Note : Annual summary rept. Sep-Dec 80,


Personal Author(s) : Ascher,M S

PDF Url : ADA140715

Report Date : 30 Jan 1981

Pagination or Media Count : 46

Abstract : Clinical studies of Q fever vaccine have been undertaken with screening of volunteers for humoral and cellular immune reactivity to specific Q fever antigens. A rapid and simplified immunofluorescent procedure has been developed for serodiagnosis of Q fever and tularemia suitable for field use. Excellent correlation exists between the results of this procedure and standard complement fixation testing for diagnosis of Q fever. Lot-to-lot variability of phase I Q fever vaccine has been assessed by in vitro lymphocyte transformation testing of immune guinea pigs. There is a consistent response between lots of vaccine by this technique and no evidence of endotoxin contamination in the vaccine. Delayed hypersensitivity skin testing of guinea pigs with Q fever antigen has revealed granulomatous changes with giant cell prominence. The immunologic basis of the granulomatous response is under analysis.

Descriptors :   *Vaccines, *Q fever, Immunology, Antigens, Serodiagnosis, Fluorescence, Immunity, Response(Biology), Guinea pigs, Immunoassay

Subject Categories : Medicine and Medical Research

Distribution Statement : APPROVED FOR PUBLIC RELEASE