Accession Number : ADA140739

Title :   Potential for Therapy with Immune Interferon.

Descriptive Note : Annual rept. 1 May 83-30 Apr 84,

Corporate Author : MASSACHUSETTS UNIV MEDICAL SCHOOL WORCESTER

Personal Author(s) : Ennis,F A

PDF Url : ADA140739

Report Date : 30 Apr 1984

Pagination or Media Count : 17

Abstract : It is known from in vitro studies that immune interferon can influence the host response to virus infections in several ways, e.g., aids in the induction of cytotoxic T lymphocyte responses, by protecting host cells including macrophages against viral infection, by activating macrophages, and by enhancing the expression of HLA and B antigens. The goal of this study is to determine the role of immune interferon in vivo in recovery from challenge with virus infections. Data indicated: (1) Cytotoxic T lymphocytes (Tc) are very effective immunotherapeutic agents in treating viral pneumonia. (2) The effective Tc are MHC and virus specific. (3) The Tc produce immune interferon when they recognize specific viral and MHC antigens on the infected target cell. (4) Gamma interferon can be detected in the cytoplasm of these antigen stimulated lymphocytes shortly after exposure to infected target cells. (5) Clones of virus specific cytotoxic or helper Tc which produce gamma interferon, have been developed and will be used in immunotherapy studies.

Descriptors :   *Interferon, Immunity, Virus diseases, Therapy, Lymphocytes, In vivo analysis, Recovery, Response(Biology)

Subject Categories : Medicine and Medical Research

Distribution Statement : APPROVED FOR PUBLIC RELEASE