Accession Number : ADA141738

Title :   Topical Hazard Evaluation Program of Candidate Insect Repellents of AI3-38359a, AI3-38282.

Descriptive Note : Final rept. Apr 82-Mar 84,

Corporate Author : ARMY ENVIRONMENTAL HYGIENE AGENCY ABERDEEN PROVING GROUND MD

Personal Author(s) : Wade,J V ; Harvey,J G , Jr

PDF Url : ADA141738

Report Date : Mar 1984

Pagination or Media Count : 11

Abstract : These compounds produced no primary irritation of the intact skin and no greater than mild primary irritation of the intact skin and no greater than mild primary irritation of the skin surrounding an abrasion. Chemicals AI3-38359a and AI3-38866a produced mild injury to the cornea and, in addition, some injury to the conjunctiva. Chemicals AI3-38277a, AI3-38865a, and AI3-38866a produced moderate injury to the cornea and, in addition, some injury to the conjunctiva. This injury had healed by 7 days post-application. Chemicals AI3-38859a and AI3-38282 produced moderate to marked sensitization in five of ten, and four of ten, guinea pigs, respectively. The other chemicals did not produce sensitization reactions. All tested chemicals did not cause a photochemical irritation reaction and demonstrated slight to moderate oral toxicity.

Descriptors :   *Insect repellents, Toxic hazards, Skin(Anatomy), Irritation, Cornea, Guinea pigs, Test and evaluation

Subject Categories : Toxicology

Distribution Statement : APPROVED FOR PUBLIC RELEASE