Accession Number : ADA180344

Title :   Lassa Fever Immune Plasma.

Descriptive Note : Final rept. (Annual) 1 Aug 84-30 Jun 85,

Corporate Author : COLUMBIA UNIV NEW YORK

Personal Author(s) : Frame,John D

PDF Url : ADA180344

Report Date : May 1986

Pagination or Media Count : 53

Abstract : Prevention of Lassa Fever requires elucidation of its epidemiology, and will likely require the preparation and use of a vaccine. However, investigations in to Lassa Virus infection carry a definite risk, and measures should be available to protect investigators as well as patients. Thus, reasearch into the epidemiology and pathogenesis of LF, in the nature of the virus, and in the development of a preventive vaccine appear to be of high priority if this hemorrhagic fever is to be brought under control. Plasma donors were identified by continued serological testing of febrile patients in hospitals, and by attempts at virus isolation. Potential donors were requested to submit sera for testing for LV NA, and those with adequate LNI were asked to submit to plasmapheresis. Epidemiologicalinvestigations were carried out among patients found to have LF; villages were selected for differences that might elucidate factors contributing to varying prevalences of LVA. Keywords: Arboviruses.

Descriptors :   *ARBOVIRUSES, *HEMORRHAGIC FEVERS, *EPIDEMIOLOGY, *VIRUS DISEASES, *IMMUNE SERUMS, DONORS(MEDICINE), FEVERS, HOSPITALS, IMMUNITY, ISOLATION, PATHOGENESIS, PATIENTS, PREVENTION, VACCINES, VILLAGES, VIRUS DISEASES, VIRUSES, ANTIBODIES, BLOOD PLASMA, IMMUNOLOGY

Subject Categories : Medicine and Medical Research
      Pharmacology

Distribution Statement : APPROVED FOR PUBLIC RELEASE