Accession Number : ADA180545

Title :   Stability Studies of Bis(Pyridiniumaldoxime) Reactivators of Organophosphate-Inhibited Acetylcholinesterase,

Corporate Author : WALTER REED ARMY INST OF RESEARCH WASHINGTON DC

Personal Author(s) : Lin,Ai J. ; Klayman,Daniel L.

Report Date : AUG 1986

Pagination or Media Count : 3

Abstract : Relative stability studies of three organophosphate-inhibited acetylcholinesterase reactivators, (Hl-6), (MMB-4), (TMB-4) were carried out by semiquantitative TLC and NMR methods. TMB-4 appears to be most, and Hl-6 the least stable of the three compounds. The stability of these reactivators decreases with increasing pH. TMB-4 was stable under both neutral and basic conditions at room temperature. Deuterium exchange of the methylene protons of MMB-4 in D2O and of the protons at the 2- and 6- positions of the pyridinum ring of TMB-4 IN NaOD/D2O were observed. Reprints.

Descriptors :   DEUTERIUM, EXCHANGE, METHYLENES, NEUTRAL, PROTONS, REPRINTS, ROOM TEMPERATURE, STABILITY

Subject Categories : Organic Chemistry

Distribution Statement : APPROVED FOR PUBLIC RELEASE