Accession Number : ADA180858

Title :   Evidence for an Involvement of NMDA (N-methyl-D-aspartate) Receptor Mechanisms in Experience-Dependent Plasticity of Kitten Striate Cortex.

Descriptive Note : Technical rept.,

Corporate Author : BROWN UNIV PROVIDENCE RI CENTER FOR NEURAL SCIENCE

Personal Author(s) : Kleinschmidt,A. ; Bear,M. F. ; Singer,W.

Report Date : 20 MAY 1987

Pagination or Media Count : 19

Abstract : Intracortical infusion of the NMDA ('N-methyl-D-aspartate') receptor blocker 2-amino-5-phosphonovaleric acid (APV) renders kitten striate cortex resistant to the effects of monocular deprivation. In addition, one week of APV treatment produces a striking loss of orientation selectivity in area 17. These data support the hypothesis that crucial variables for the expression of activity dependent synaptic modifications are a critical level of postsynaptic activation and calcium entry through gates linked to NMDA receptors.

Descriptors :   *VISUAL CORTEX, *BIOCHEMISTRY, *NERVE TRANSMISSION, LOSSES, MODIFICATION, ORIENTATION(DIRECTION), SENSE ORGANS, SYNAPSE, CALCIUM, VISION, DEPRIVATION, EYE, LINKAGES

Subject Categories : Biochemistry
      Anatomy and Physiology

Distribution Statement : APPROVED FOR PUBLIC RELEASE