Accession Number : ADA181041

Title :   Effects of Atropine, 2-PAM, or Pyridostigmine in Euvolemic or Hemorrhagic Conscious Swine.

Descriptive Note : Rept. for 1984-1987,

Corporate Author : LETTERMAN ARMY INST OF RESEARCH PRESIDIO OF SAN FRANCISCO CA

Personal Author(s) : Wade,C E ; Waring,P P ; Trail,D S ; Williams,B F ; Bonner,G D

PDF Url : ADA181041

Report Date : Apr 1987

Pagination or Media Count : 26

Abstract : We investigated the effects of atropine, pralidoxime chloride (2-PAM), or pyridostigmine on the physiological and metabolic responses to hemorrhagic hypotension in conscious swine. All treatments were evaluated in euvolemic and hemorrhaged animals (36 ml of blood/kg/over one hour). Hemorrhage reduced blood pressure by 58 mmHg and decreased plasma acetylcholinesterase (AChE) activity by 18% in the control animals (n=6). Atropine injection increased heart rate similarly in hemorrhaged (n=6) and euvolemic (n=6) animals. Blood pressure was also transiently elevated following atropine administration. Injection of 2-PAM acutely elevated the levels of plasma lactate and plasma AChE, but values were similar to those in the untreated animals within 15 min in both euvolemic (n=7) and hemorrhaged (n=7) animals. Treatment with pyridostigmine for 3 days reduced plasma AChE by 37% and red blood cell AChE by 35% (n=12). Pretreatment with pridostigmine had no effect on any of the responses to hemorrhage. Posthemorrhage treatment with atropine or 2-PAM or pretreatment with pyridostigmine had no detrimental effects on the physiological or metabolic responses to moderate hemorrhage in conscious swine. Keywords: Wounds and injuries; Trauma.

Descriptors :   *ATROPINE, *HEMORRHAGE, *HYPOTENSION, ACETYLCHOLINESTERASE, CONTROL, ERYTHROCYTES, HEART RATE, INJECTION, LABORATORY ANIMALS, METABOLISM, PHYSIOLOGICAL EFFECTS, ANIMALS, BLOOD PRESSURE, REDUCTION, RESPONSE, RESPONSE(BIOLOGY), SWINE, TRAUMA

Subject Categories : Pharmacology
      Medicine and Medical Research

Distribution Statement : APPROVED FOR PUBLIC RELEASE