Accession Number : ADA181319

Title :   Circadian Variation in Host Defense.

Descriptive Note : Final rept. Nov 84-Mar 87,

Corporate Author : MICHIGAN UNIV ANN ARBOR DEPT OF PHYSIOLOGY

Personal Author(s) : Kluger,Matthew J

PDF Url : ADA181319

Report Date : 21 May 1987

Pagination or Media Count : 5

Abstract : The circadian rhythm in body temperature is thought to be due to a rhythm in the thermoregulatory set-point . The overall goal of our research was to determine whether this represents a circadian fever. If this hypothesis is correct, then antipyretic drugs should attenuate the rhythm in body temperature. We have found that administration of a variety of antipyretic drugs to rats markedly reduced their nighttime elevation in body temperature. These data suggest to us that prostaglandins are probably involved in the circadian rhythm in body temperature. We have attempted to determine whether this rhythm in prostaglandins is dependent on a rhythm in circulating concentrations of interleukin-1 (IL-1). Based on studies with rats and human beings using bioassays and immunoassays, we have been unable to detect any rhythm in plasma concentration of IL-1. We conclude that it is unlikely that circulating IL-1 has a role in the rhythm in body temperature. If IL-1 influences the circadian rhythm in body temperature, it may do so at the level of the hypothalamus or at some other central nervous site.

Descriptors :   *BODY TEMPERATURE, *CIRCADIAN RHYTHMS, *ANTIPYRETICS, BIOASSAY, CENTRAL NERVOUS SYSTEM, DEFENSE SYSTEMS, ELEVATION, HUMANS, HYPOTHALAMUS, HYPOTHESES, IMMUNOASSAY, NIGHT, PROSTAGLANDIN, RATS, SITES, FEVERS

Subject Categories : Anatomy and Physiology
      Pharmacology

Distribution Statement : APPROVED FOR PUBLIC RELEASE