Accession Number : ADA181471

Title :   Effect of Organophosphate Compounds on Renal Function and Transport.

Descriptive Note : Annual rept. 1 Sep 82-31 Aug 83,

Corporate Author : NEBRASKA UNIV MEDICAL CENTER OMAHA DEPT OF PHARMACOLOGY

Personal Author(s) : Berndt,William O

PDF Url : ADA181471

Report Date : 15 Sep 1983

Pagination or Media Count : 49

Abstract : The present program was undertaken to examine whether or not organophosphate cholinesterase inhibitors have effects on renal function and transport in the rat. These studies were proposed because of several suggestions in the scientific literarure that cholinergic agents may have direct effects on renal transport above and beyond effects exerted through changes in renal blood flow. The organophosphate inhibitors are particularly suitable because of their long lasting effects. Studies in unanesthetized rats indicated that DFP caused increased urine flow, a decreased osmolality of the urine, an increased sodium excretion, and an increased excertion of protein, glucose and blood. No effects were observed on the excretion of potassium. The effects were of a transient nature with a return to the control status by 24 hours. Studies on anesthetized animals confirmed the results on the unanesthetized animals. Renal cortex slices were done to determine whether or not direct effects of organophosphate compounds on renal slice function could be observed. DFP was found to inhibit the transport of p-aminohippurate (PAH) whether administered in vivo or added to slices in vitro, while effects on the transport of the cation tetraethylammonium were produced less regularly.

Descriptors :   *ORGANOPHOSPHATES, *CHOLINESTERASE INHIBITORS, *KIDNEYS, *TRANSPORT, BLOOD, BLOOD CIRCULATION, EXCRETION, FLOW, GLUCOSE, IN VITRO ANALYSIS, IN VIVO ANALYSIS, INHIBITORS, OSMOSIS, PARASYMPATHOLYTIC AGENTS, PHOSPHATES, POTASSIUM, PROTEINS, RATS, SODIUM, URINE, TOXICITY, BIOCHEMISTRY, LABORATORY TESTS, IN VITRO ANALYSIS, BLADDER(URINARY)

Subject Categories : Toxicology
      Biochemistry

Distribution Statement : APPROVED FOR PUBLIC RELEASE