Accession Number : ADA181691

Title :   Synthesis of Nucleoside Mono- and Dialdehydes as Antiviral Agents.

Descriptive Note : Annual rept. 15 Nov 85-14 Nov 86,

Corporate Author : ROCHESTER INST OF TECH NY

Personal Author(s) : Neenan,John P

PDF Url : ADA181691

Report Date : 15 Dec 1986

Pagination or Media Count : 20

Abstract : Seven nucleoside 2', 3' -dialdehydes were synthesized by periodic oxidation of inosine, 6-methylmercaptopurine riboside, thymine riboside, guanosine, 5'-fluoro-5'deoxyadenosine, 8-bromoadenosine, and N6, N6-dimethylaminopurine riboside, respectively. The resultant nucleoside dialdehydes, as well as the intermediate 5'-fluoro-5'deoxyadenosine, were submitted to the USAMRIID antiviral screening program. Keywords: Antiviral agents.

Descriptors :   *ANTIVIRAL AGENTS, *SYNTHESIS(CHEMISTRY), INOSINE, NUCLEOSIDES, OXIDATION, ALDEHYDES, ADENOSINE

Subject Categories : Pharmacology
      Organic Chemistry

Distribution Statement : APPROVED FOR PUBLIC RELEASE