Accession Number : ADA181755
Title : Genotoxicity of Dyes Present in Colored Smoke Munitions.
Descriptive Note : Final rept. 1 Nov 84-1 Jun 86,
Corporate Author : LOVELACE BIOMEDICAL AND ENVIRONMENTAL RESEARCH INST ALBUQUERQUE NM INHALATION TOXICOLOGY RESEARCH INST
Personal Author(s) : Henderson,Rogene F ; Brooks,Antone L ; Hanson,Ray L
PDF Url : ADA181755
Report Date : 07 Jul 1986
Pagination or Media Count : 125
Abstract : The Lovelace Inhalation Toxicology Research Institute has been coduction genetic toxicology studies on organic dyes used in colored smoke munitions. This report summarizes the results of tests to determine the genotoxic potency of the dyes toward both bacteria and mammalian cells in vitro. The tests were conducted to detect mutations in bacteria and mammalian cells and to determine cell killing, alterations in cell cycle kinetics, sister chromatid exchanges, and chromosome aberration induction in mammalian cells. The dyes evaluated in the report include Solvent Red 24, Solvent Red 1, Disperse Red 11 and terephthalic acid. Disperse Red 11 had chemical contamination that seemed to be responsible for some mutagenic activity. Keywords: Disperse Red 11, Solvent Red 24, Solvent Red 1, Genotoxicity, Dyes, Disperse Red 15.
Descriptors : *DYES, *CELLS(BIOLOGY), *COLORED SMOKES, *SMOKE MUNITIONS, *TOXICITY, BACTERIA, CHEMICAL CONTAMINATION, CHROMOSOMES, DISTORTION, INHALATION, IN VITRO ANALYSIS, MAMMALS, MUTATIONS, CYCLES, KINETICS, CHROMATIN, GENETICS, TOXICOLOGY, MUTAGENS, ORGANIC COMPOUNDS, SOLVENT DYES, POTENCY, TIN
Subject Categories : Toxicology
Ammunition and Explosives
Distribution Statement : APPROVED FOR PUBLIC RELEASE