Accession Number : ADA181755

Title :   Genotoxicity of Dyes Present in Colored Smoke Munitions.

Descriptive Note : Final rept. 1 Nov 84-1 Jun 86,

Corporate Author : LOVELACE BIOMEDICAL AND ENVIRONMENTAL RESEARCH INST ALBUQUERQUE NM INHALATION TOXICOLOGY RESEARCH INST

Personal Author(s) : Henderson,Rogene F ; Brooks,Antone L ; Hanson,Ray L

PDF Url : ADA181755

Report Date : 07 Jul 1986

Pagination or Media Count : 125

Abstract : The Lovelace Inhalation Toxicology Research Institute has been coduction genetic toxicology studies on organic dyes used in colored smoke munitions. This report summarizes the results of tests to determine the genotoxic potency of the dyes toward both bacteria and mammalian cells in vitro. The tests were conducted to detect mutations in bacteria and mammalian cells and to determine cell killing, alterations in cell cycle kinetics, sister chromatid exchanges, and chromosome aberration induction in mammalian cells. The dyes evaluated in the report include Solvent Red 24, Solvent Red 1, Disperse Red 11 and terephthalic acid. Disperse Red 11 had chemical contamination that seemed to be responsible for some mutagenic activity. Keywords: Disperse Red 11, Solvent Red 24, Solvent Red 1, Genotoxicity, Dyes, Disperse Red 15.

Descriptors :   *DYES, *CELLS(BIOLOGY), *COLORED SMOKES, *SMOKE MUNITIONS, *TOXICITY, BACTERIA, CHEMICAL CONTAMINATION, CHROMOSOMES, DISTORTION, INHALATION, IN VITRO ANALYSIS, MAMMALS, MUTATIONS, CYCLES, KINETICS, CHROMATIN, GENETICS, TOXICOLOGY, MUTAGENS, ORGANIC COMPOUNDS, SOLVENT DYES, POTENCY, TIN

Subject Categories : Toxicology
      Ammunition and Explosives

Distribution Statement : APPROVED FOR PUBLIC RELEASE