Accession Number : ADA181765

Title :   Degenerative Enzymes.

Descriptive Note : Annual progress rept. Jul 85-Apr 87,

Corporate Author : TEXAS A AND M UNIV COLLEGE STATION DEPT OF BIOCHEMISTRY AND BIOPHYSICS

Personal Author(s) : Meyer,Edgar F , Jr

PDF Url : ADA181765

Report Date : 30 Apr 1987

Pagination or Media Count : 3

Abstract : To date, using high-resolution X-ray crystallography, we have determined the structures of 10 small molecule ligands or inhibitors to the serine protease, porcine pancreatic elastase. These complexes reveal details of binding or steps on the catalytic pathway (Michaelis complex, acyl intermediate, transition state intermediate) that now can be used to design novel, more specific inhibitors or intermediates. Keywords: Enzyme inhibitors.

Descriptors :   *ENZYME INHIBITORS, *PEPTIDE HYDROLASES, ENZYMES, PANCREAS, SWINE, INHIBITORS, CRYSTALLOGRAPHY, HIGH RESOLUTION, X RAYS, SERINE, TRANSITIONS, MOLECULAR STRUCTURE, LIGANDS

Subject Categories : Biochemistry
      Pharmacology

Distribution Statement : APPROVED FOR PUBLIC RELEASE