Accession Number : ADA181920

Title :   Cytochemical Studies on Acetylcholine Synthesis and Metabolism in the Vestibular Cerebellum.

Descriptive Note : Final rept. 1 Sep 82-31 Aug 86,

Corporate Author : HARVARD UNIV CAMBRIDGE MA

Personal Author(s) : Paley,Sanford L

PDF Url : ADA181920

Report Date : 31 May 1987

Pagination or Media Count : 9

Abstract : An immunocytochemical study of the cerebellar cortex was carried out in order to determine the distribution and correlations of several neuroactive agents, vis., acetylcholine, taurine, gamma aminobutyric acid, and several peptides. Purkinje cells containing acetylcholine and its metabolic enzymes are most common in the flocculondular lobe and they are randomly distributed without a clear pattern. In contrast Purkinje cells containing the enzymes glutamic acid decarboxylase (for GABA), or cystein-sulfinic acid decarboxylase (for taurine) or the peptide motilin are organized into microzones, longitudinal strips that alternate with strips containing other chemicals. Some Purkinje cells contain more than one neuroactive agent. These chemically characterized strips are closely matched with the location of mossy fibers representing the distal parts of the lower limbs. Keywords: Immunocytochemistry.

Descriptors :   *ACETYLCHOLINE, *CEREBELLUM, *METABOLISM, *CYTOCHEMISTRY, *BIOSYNTHESIS, *IMMUNOCHEMISTRY, CARBOXY LYASES, IMMUNOLOGY, PATTERNS, PEPTIDES, SYNTHESIS, VESTIBULAR APPARATUS, ENZYMES, EXTREMITIES, BUTYRIC ACIDS, CHEMICALS

Subject Categories : Biochemistry
      Anatomy and Physiology

Distribution Statement : APPROVED FOR PUBLIC RELEASE