Accession Number : ADA182019

Title :   A Program for Study of Skeletal Muscle Catabolism Following Physical Trauma.

Descriptive Note : Rept. no. 5 (Final) 1 Oct 81-13 Nov 85, Annual rept. Aug 84-Nov 85,

Corporate Author : HARVARD MEDICAL SCHOOL BOSTON MASS DEPT OF SURGERY

Personal Author(s) : Wilmore,Douglas W

PDF Url : ADA182019

Report Date : 15 May 1986

Pagination or Media Count : 29

Abstract : This contract examines methods of attenuating post traumatic metabolic responses. The increased glucose production which occurs following infection and injury in sleep was not decreased by infusion of beta-hydroxybutyrate; similar studies in normal of fasting animals demonstrated prompt attenuation. Net proteolysis following operation was reduced by amino acid infusion. Solutions fortified with branched chain amino acid exerted no beneficial effect. Post traumatic skeletal muscle proteolysis could be attenuated by alpha and beta adreneric blockade or epidural anesthesia. Skeletal muscle nitrogen balance could be predicted from branched chain amino acid uptake and changes of amino acid concentrations in the free amino acid pool. Keywords: Skeletal muscle proteolysis, Glutamine, Branched chain amino acids, Adrenergic regulation.

Descriptors :   *METABOLIC DISEASES, *CATABOLISM, *TRAUMA, *MUSCLES, AMINO ACIDS, CONCENTRATION(COMPOSITION), AMINO ACIDS, CHAINS, GLUTAMINE, WOUNDS AND INJURIES, ATTENUATION, AMINO ACIDS, INFUSIONS, AMINO ACIDS, INFUSIONS, GLUCOSE, PRODUCTION, INFECTIOUS DISEASES, FOOD DEPRIVATION, NORMALITY, BALANCE, MUSCULOSKELETAL SYSTEM, NITROGEN, PEPTIDE HYDROLASES, PROTEIN METABOLISM, HYDROXYL RADICALS, BUTYRATES, ANESTHETICS, SHEEP

Subject Categories : Medicine and Medical Research
      Pharmacology

Distribution Statement : APPROVED FOR PUBLIC RELEASE