Accession Number : ADA182561

Title :   Acetylcholinesterase and Acetylcholine Receptor.

Descriptive Note : Annual rept. 15 Sep 84-14 Sep 85,

Corporate Author : BRANDEIS UNIV WALTHAM MA DEPT OF CHEMISTRY

Personal Author(s) : Cohen,Saul G

PDF Url : ADA182561

Report Date : 21 Jan 1986

Pagination or Media Count : 33

Abstract : We are studying the properties of the active site, and the region peripheral to it, of acetylcholinesterase (AcChE), the enzyme which hydrolyzes and thus terminates the action of the important neurotransmitter acetylcholine (AcCh). We have studied the response of the enzyme to synthesized substrates and inhibitors of varied structure for indications about the parts of the enzyme that are complementary to these substrates. From this information radioactive active-site-directed irreversible inhibitors have been designed for use in labeling amino acids in the active site. In this work AcChE was isolated from Torpedo nobiliana. Novel uncharged reversible inhibitors were also prepared for study of their action on the AcCh receptor by Professor J.B. Cohen, Department of Anatomy and Neurobiology, Washington University School of Medicine, St. Louis.

Descriptors :   *ACETYLCHOLINE, *ACETYLCHOLINESTERASE, SENSE ORGANS, ENZYMES, NEUROBIOLOGY, PARTS, SUBSTRATES, NERVE TRANSMISSION, REVERSIBLE, SYNTHESIS, CHOLINESTERASE INHIBITORS

Subject Categories : Biochemistry

Distribution Statement : APPROVED FOR PUBLIC RELEASE