Accession Number : ADA182716

Title :   The Synthesis and Study of Azole Carboxamide Nucleosides as Agents Active Against RNA Viruses.

Descriptive Note : Final rept. 1 Apr 79-31 Aug 85, Annual rept. 1 Sep 84-31 Aug 85,

Corporate Author : BRIGHAM YOUNG UNIV PROVO UT

Personal Author(s) : Robins,Roland K ; Revankar,Ganapathi R

PDF Url : ADA182716

Report Date : 15 Sep 1986

Pagination or Media Count : 84

Abstract : In an effort to prepare compounds with potential antiviral activity against RNA viruses having substantial implications from a global epidemiological standpoint, a number of azole heterocycles and the corresponding nucleosides structurally related to ribavirin have been synthesized. 1,2,4-Triazole, thiazole, pyrrole, pyrazole, purine, pyrrolo(2,3-d) pyrimidine and pyrimido(5,4-d) pyrimidine ring systems have particularly been selected. New and improved synthetic procedures have been developed during the course of this study. The compounds thus synthesized in gram quantities were tested at the U.S. Army Medical Research Institute of Infectious Diseases, Fort Detrick, against RVF, VEE, PITCH, YF, SF, VSV, and KHF viruses in vitro and in vivo. Keywords: Ribaviran, Rift Valley fever virus; Lass virus; Machupovirus; Dengue virus; Pichinde virus; Hantaan virus; Retroviruses.

Descriptors :   *ANTIVIRAL AGENTS, *AMIDES, *AZOLES, *CARBOXYL GROUPS, *NUCLEOSIDES, ARMY RESEARCH, MEDICAL RESEARCH, DENGUE, GROUP B ARBOVIRUSES, INFECTIOUS DISEASES, PYRROLES, RIBONUCLEIC ACIDS, VIRUSES, VENEZUELAN EQUINE ENCEPHALOMYELITIS VIRUS, IN VIVO ANALYSIS, PYRIMIDINES, RINGS, SYNTHESIS, VIRUSES

Subject Categories : Pharmacology

Distribution Statement : APPROVED FOR PUBLIC RELEASE