Accession Number : ADA182764

Title :   Final Technical Report on Contract N00014-83-D-0689,

Corporate Author : AMERICAN SOCIETY FOR ENGINEERING EDUCATION WASHINGTON DC

Personal Author(s) : Hall,Kathleen S

PDF Url : ADA182764

Report Date : 17 Jul 1987

Pagination or Media Count : 29

Abstract : The catalytic hydrolysis of Diisopropylflurophosphate (DEP) and other phosphorus esters have been of great interest to the Navy. The discovery of the enzymes DFPase shows great promise for the hydrolysis of DEP, but a major problem with enzymes is their poor stability and limited available quantities. By investigating the use of enzyme mimics for the hydrolysis of Dep the stability and quantity problems can be avoided. One of the best known molecules used in biomimetic studies is cyclodextrin (CD). In this research we studied the inclusion complex of DFP with alpha, beta, and gamma cylcodextrin using Nuclear Magnetic Resonance(NMR) techniques. Cyclodextrins are cyclic oligomers of glucose.

Descriptors :   *DEXTRINS, *ORGANIC PHOSPHORUS COMPOUNDS, *CYCLIC COMPOUNDS, *SYNTHESIS(CHEMISTRY), *FLUORESCENT DYES, HYDROLYSIS, ENZYMES, MOLECULES, QUANTITY, CYCLES, GLUCOSE, POLYMERS, ESTERS, PHOSPHORUS, CATALYSIS, PHOSPHORIC MONOESTER HYDROLASES, CHEMILUMINESCENCE

Subject Categories : Organic Chemistry

Distribution Statement : APPROVED FOR PUBLIC RELEASE