Accession Number : ADA183301

Title :   Range Finding 14-Day and 90-Day Subchronic Feeding Studies with N,N-Dipropylcyclohexanecarboxamide in Rats. Phase 4.

Descriptive Note : Study rept. Jun 84-Dec 86,

Corporate Author : ARMY ENVIRONMENTAL HYGIENE AGENCY ABERDEEN PROVING GROUND MD

Personal Author(s) : Macko,Joseph A , Jr ; Muehsam,William T

PDF Url : ADA183301

Report Date : Dec 1986

Pagination or Media Count : 69

Abstract : This study was conducted to determine the toxicity of N,N,-Dipropylcyclohexanecarboxamide following repeated oral exposure to various doses of the technical grade compound. This evaluation will assist in advising on the health hazards associated with accidental oral exposure to this material. The low food consumption, probably due to the decreased rat body weight in high dose groups created great physiological stress and affected blood clinical chemistry values. Significant increases occurred in male rat liver organ-to-body weight ratios in all three dose levels at the 45 and 90 day necropsies during the 90-day feeding study. A no effect dose was not achieved during this study. Additional testing would be required to confirm a no effect dose level. It is concluded that a toxic hazard may exist from a prolonged significant oral exposure to N,N-Dopropylcyclohexanecarboxamide. It is recommended that further evaluation of this compound as a candidate insect repellent be discontinued due to the deleterious liver involvement caused by N,N-Dipropylcyclohexanecarboxamide at levels as low as 64 mg/Kg in male rats.

Descriptors :   *INSECT REPELLENTS, *TOXICITY, ACCIDENTS, EXPOSURE(GENERAL), ORAL INTAKE, BLOOD, CHEMISTRY, CLINICAL MEDICINE, DOSAGE, STRESS(PHYSIOLOGY), FOOD CONSUMPTION, LEVEL(QUANTITY), HAZARDS, HEALTH, LIVER, MALES, RATS, CARBOXYL GROUPS, AMIDES, HEXANES, CYCLIC COMPOUNDS, PROPYL RADICALS, TOXIC HAZARDS

Subject Categories : Toxicology
      Environmental Health and Safety

Distribution Statement : APPROVED FOR PUBLIC RELEASE