Accession Number : ADA183725

Title :   Treatment of Laser Induced Retinal Injuries.

Descriptive Note : Annual rept. Feb 85-Jan 86,

Corporate Author : TEL-AVIV UNIV (ISRAEL)

Personal Author(s) : Belkin,Michael ; Naveh,Nava

PDF Url : ADA183725

Report Date : 02 Apr 1986

Pagination or Media Count : 23

Abstract : The effect of argon laser irradiation of the retina at various energy levels on PGE2 production by the retina-choroid, and PGE2 and protein accumulation in the vitreous cavity, was investigated and compared to the effects of sham exposures. The effect of steroid treatment on PGE2 levels following laser exposure was also examined. Results showed that both single and multiple suprathreshold applications were characterized by a biphasic increase in retinal PGE2 production, whereas multiple subthreshold exposure elicited an increase in PGE2 production of much longer duration. In eyes subjected to sham exposure, the increase in retinal PGE2 production was evident as a single peak. Moreover laser-induced retinal burns at most of the energy levels studied, as well as sham exposure resulted in a accumulation of PGE2 and/or protein in the vitreous body. Keywords: Prostaglanidn; Vitreal protein levels.

Descriptors :   *LASER DAMAGE, *RADIATION EFFECTS, *RETINA, *ARGON LASERS, ACCUMULATION, ARGON LASERS, BURNS(INJURIES), CAVITIES, ENERGY LEVELS, EXPOSURE(GENERAL), EYE, IRRADIATION, LASER BEAMS, LASERS, PEAK VALUES, PROTEINS, STEROIDS, SUBSURFACE, THRESHOLD EFFECTS, VITREOUS STATE, WOUNDS AND INJURIES

Subject Categories : Radiobiology

Distribution Statement : APPROVED FOR PUBLIC RELEASE