Accession Number : ADA184309

Title :   Genetics, Structure and Functional Features of the RNA Modification Enzyme, tRNA psi Synthase I.

Descriptive Note : Summary rept. 1 Feb 84-31 Jan 85,

Corporate Author : CALIFORNIA UNIV OAKLAND NAVAL BIOSCIENCES LAB

Personal Author(s) : Kammen,Harold O ; Marvel,Christopher C

PDF Url : ADA184309

Report Date : Jan 1985

Pagination or Media Count : 46

Abstract : Nucleoside modifications are significant structural components of most classes of cellular Ribonucleic Acids. About 50 RNA modifications are known, varying in complexity from simple base or sugar methylations to multifunctional heterocyclic groups. The use of RNA modification enzymes as probes of protein-nucleic acid interaction has been limited by the lack of pure enzymes of this type. Our goal is to develop the pseudouridine modification system for this purpose, by identifying the enzymes, genes and molecular interactions involved in the synthesis of this nucleoside.

Descriptors :   *SYNTHASES, *RIBONUCLEIC ACIDS, *GENETICS, *MOLECULAR BIOLOGY, MOLECULAR STRUCTURE, MODIFICATION, GENES, NUCLEOSIDES

Subject Categories : Biochemistry
      Genetic Engineering and Molecular Biology

Distribution Statement : APPROVED FOR PUBLIC RELEASE