Accession Number : ADA184413

Title :   Synthetic Helizyme Enzymes.

Descriptive Note : Annual rept. Jul 86-Jul 87,

Corporate Author : COLORADO UNIV HEALTH SCIENCES CENTER DENVER

Personal Author(s) : Stewart,John M ; Hahn,Karl

PDF Url : ADA184413

Report Date : 18 Aug 1987

Pagination or Media Count : 12

Abstract : The object of this project is to design and synthesize totally new, totally synthetic small molecules having specific enzyme activity. The ultimate goal is to design and synthesize a molecule with cholinesterase activity. The initial goal is to design and synthesize a molecule with chymotryspin activity. Computer-assisted molecular graphics is being used to model chymotryspin from the known X-ray structure and extract the amino acid residues responsible for catalytic activity and substrate binding. A synthetic framework of amphipathic helical peptides is being designed and will be synthesized to hold the essential amino acid residues in the conformation necessary for enzyme activity.

Descriptors :   *MOLECULAR BIOLOGY, *ENZYMES, *BIOENGINEERING, SYNTHESIS, MODELS, PEPTIDES, CHYMOTRYPSIN, MOLECULAR STRUCTURE, BIOMOLECULES, ACETYLCHOLINESTERASE, COMPUTER GRAPHICS, AMINO ACIDS

Subject Categories : Genetic Engineering and Molecular Biology
      Biochemistry

Distribution Statement : APPROVED FOR PUBLIC RELEASE