Accession Number : ADA184892

Title :   Detoxification of Acetylcholinesterase Inhibitors.

Descriptive Note : Final rept. 1 Jun 84-30 Nov 86,

Corporate Author : TEXAS A AND M RESEARCH FOUNDATION COLLEGE STATION

Personal Author(s) : Wild, James R

PDF Url : ADA184892

Report Date : 19 Feb 1987

Pagination or Media Count : 9

Abstract : The research support by ARO contract 212888-LS entitled Detoxification of acetylcholinesterase inhibitors has resulted in the cloning and partial sequence of two opd genes from Pseudomonas diminuta and Flavobacterium species. It has been possible to isolate the enzyme in association with a small membrane fraction and initiate e an evaluation of the organophosphate hydrolase. Collaborative interactions with research scientists at the Chemical Defense Research Command have suggested that the Pseudomonas species is competent to degrade selected types of biological neurotoxins.

Descriptors :   *CHOLINESTERASE INHIBITORS, *DETOXIFICATION, *HYDROLASES, ACETYLCHOLINESTERASE, TOXINS AND ANTITOXINS, PSEUDOMONAS, CLONES, MEMBRANES(BIOLOGY), ORGANOPHOSPHATES, HYDROLYSIS, ESTERASES, EUBACTERIALES

Subject Categories : Toxicology
      Biochemistry

Distribution Statement : APPROVED FOR PUBLIC RELEASE