Accession Number : ADA185436

Title :   A Program for the Study of Skeletal Muscle Catabolism Following Physical Trauma.

Descriptive Note : Annual rept. 21 Feb 86-20 Feb 87,

Corporate Author : BRIGHAM AND WOMEN'S HOSPITAL BOSTON MA

Personal Author(s) : Wilmore, Douglas W

PDF Url : ADA185436

Report Date : 15 Mar 1987

Pagination or Media Count : 19

Abstract : Following laparotomy and retroperitoneal dissection, dogs increase skeletal muscle proteolysis and excrete increased quantities of nitrogen in the urine. Pretreatment with a cyclo-oxygenase inhibitor (Ibuprofen) diminished this response in the 5 animals studied to date. More animals are required to make firm conclusions as to the effectiveness of this therapy on post traumatic metabolism.

Descriptors :   *HYDROLYSIS, *MUSCLE PROTEINS, *CATABOLISM, *ENZYME INHIBITORS, METABOLISM, PEPTIDES, URINE, NITROGEN, THERAPY, DOGS, TRAUMA

Subject Categories : Medicine and Medical Research
      Biochemistry
      Pharmacology

Distribution Statement : APPROVED FOR PUBLIC RELEASE