Accession Number : ADA185460

Title :   Studies of Altered Responses to Infection Induced by Thermal Injury.

Descriptive Note : Final rept. Jan 77-Apr 86,

Corporate Author : CALIFORNIA UNIV SAN FRANCISCO

Personal Author(s) : Miller, Carol L

PDF Url : ADA185460

Report Date : 28 Jul 1987

Pagination or Media Count : 39

Abstract : We have made the initial demonstration of the post trauma generation of T suppressor lymphocytes, and determined that nutritional depletion is not the trigger but rather the result of post injury cellular abberations, and adapted and developed a number of new assays for assessing trauma patients cellular immune function. Using these assays, we have defined a number of crucial defects in both monocyte and T cell functions which are correlated with post trauma immunosuppression. Our current hypothesis is that alterations in crucial M0 T cell interactions may be the underlying mechanism of post trauma immunosuppression. In addition, we have examined several types of prophylactic therapies which are directed toward modulating the monocyte and T cell defects we described. Our data seems to indicate that a combination of defects may be resulting in the immunocompromised trauma patient syndrome. Effective immunotherapy may require a combination of immunotherapeutic agents to contravene these multiple defects. The assays which we have developed are therefore important in the monitoring of the patients for the efficacy of immunotherapy as well as for detecting post trauma alterations in patient leukocyte function. Keywords: Coagulation, Burns(Injuries), Plasmin, Blood plasma.

Descriptors :   *IMMUNOSUPPRESSION, *RESPONSE, *RESPONSE(BIOLOGY), *STRESS(PHYSIOLOGY), *CELLS(BIOLOGY), *ANTIGEN ANTIBODY REACTIONS, *IMMUNOCHEMISTRY, *BLOOD COAGULATION, *CELLS, *BURNS(INJURIES), ASSAYING, DEFECTS(MATERIALS), DEPLETION, HYPOTHESES, INFECTIOUS DISEASES, LEUKOCYTES, MONITORING, NUTRITION, PATIENTS, PLASMIN, PREVENTIVE MEDICINE, SUPPRESSORS, THERAPY, TRAUMA, WOUNDS AND INJURIES

Subject Categories : Medicine and Medical Research

Distribution Statement : APPROVED FOR PUBLIC RELEASE