Accession Number : ADA185472

Title :   Intrinsic Cholinergic Mechanisms Regulating Cerebral Blood Flow as a Target for Organophosphate Action.

Descriptive Note : Annual rept. 30 Sep 84-29 Sep 85,

Corporate Author : CORNELL UNIV MEDICAL COLL NEW YORK LAB OF NEUROBIOLOGY

Personal Author(s) : Reis, Donald J ; Iadecola, Costantino ; Arneric, Stephen P

PDF Url : ADA185472

Report Date : Oct 1985

Pagination or Media Count : 47

Abstract : The hypothesis of this study is that intrinsic systems in the brain can produce primary vasodilation independent of metabolism, that the system is represented in the fastigial nucleus FN of the cerebellum, and that the vasodilation is mediated by the release of acetylcholine ACh adjacent blood vessels. The cholinergic vasodilation, which is maximum in the cerebral cortex, should be facilitated by organophosphates, the consequence of which will be to abolish local autoregulation, produce an enhanced dependence of the cerebral circulation upon systemic arterial pressure, and thereby render local cerebral vessels vulnerable to breakdown of the blood-brain barrier. Keywords: Cerebral blood flow; Muscarinic receptor blockade; Cholinergic vasodilation; Atropine.

Descriptors :   *ATROPINE, *CHOLINERGIC NERVES, *ORGANOPHOSPHATES, *VASODILATION, ACETYLCHOLINE, BARRIERS, BLOOD, BLOOD CIRCULATION, BLOOD PRESSURE, BLOOD VESSELS, BRAIN, CEREBELLUM, CEREBRAL CORTEX, CEREBRUM, CIRCULATION, HYPOTHESES, METABOLISM, RELEASE, SHIPS, NERVE BLOCKING, NUCLEI

Subject Categories : Anatomy and Physiology
      Biochemistry
      Pharmacology

Distribution Statement : APPROVED FOR PUBLIC RELEASE