Accession Number : ADA185490

Title :   Entropic Elastomeric Force in Protein Structure/Function.

Descriptive Note : Final rept.,

Corporate Author : ALABAMA UNIV IN BIRMINGHAM LAB OF MOLECULAR BIOPHYSICS

Personal Author(s) : Urry, Dan W

PDF Url : ADA185490

Report Date : Jul 1987

Pagination or Media Count : 37

Abstract : Entropic protein elasticity can be the result of internal chain dynamics, specifically of librational processes that become damped on chain extension. This mechanism of entropic protein elasticity allows for an understanding not only of elastin but also of the passive tension of striated muscle, of the voltage-dependent interconversion between open and closed conductance states in the sodium channel of squid nerve, and of protein elastic forces producing strain in a substrate bond during enzyme catalysis. This understanding provides a mechanism for modulating protein function, whether for example enzymatic or channel, a mechanism for the remarkable reversible structural processes that attend parturition, and mechanism for the connective tissue anomalies of wound repair and environmentally induced lung disease.

Descriptors :   *ELASTIC PROPERTIES, *PROTEINS, *MOLECULAR STRUCTURE, *ENTROPY, ANOMALIES, BONDING, CATALYSIS, CHAIN REACTIONS, CHAINS, CHANNELS, CONNECTIVE TISSUE, DAMPING, DISEASES, DYNAMICS, ENZYMES, INTERNAL, LUNG, MODULATION, NERVES, PASSIVE SYSTEMS, REPAIR, REVERSIBLE, SODIUM, STRUCTURAL PROPERTIES, SUBSTRATES, TENSION, WOUNDS AND INJURIES, PEPTIDES, FUNCTIONS, MOLECULE MOLECULE INTERACTIONS, TORSION, BENDING STRESS

Subject Categories : Biochemistry
      Genetic Engineering and Molecular Biology

Distribution Statement : APPROVED FOR PUBLIC RELEASE