Accession Number : ADA185558

Title :   The Fibronectin Binding Capacity of Demineralized Bone and Dentin.

Descriptive Note : Master's thesis,

Corporate Author : AIR FORCE INST OF TECH WRIGHT-PATTERSON AFB OH

Personal Author(s) : Pearson, Bryan S.

Report Date : 1986

Pagination or Media Count : 68

Abstract : An understanding of the basic biochemical and physiological mechanisms of wound healing is important when developing rationales for new therapies in periodontics and other surgical specialities. Reattachment or new attachment of connective tissue to root surface is frequently a goal of periodontal therapy. Experiments have recently been done to investigate the role of fibronectin in the healing of wounds involving periodontal tissues. Fibronectin is an ubiquitous glycoprotein found in both plasma and in various tissues. This study examines the fibronectin binding capacity of demineralized bone and dentin. The results indicate that in clinical use, bleeding into a surgical wound would provide endogenous fibronectin in concentrations sufficient to saturate all available collagen binding sites. The addition of exogenous fibronectin as a means of enhancing wound healing would appear to be unnecessary. Keywords: Thesis, Healing, Wounds and injuries, Dental surgery.

Descriptors :   *BINDERS, *BONES, *CONNECTIVE TISSUE, *DENTIN, *GLYCOPROTEINS, ATTACHMENT, BIOCHEMISTRY, CLINICAL MEDICINE, COLLAGEN, DEMINERALIZATION, DENTAL SURGERY, HEALING, HEMORRHAGE, PHYSIOLOGY, SURFACES, TEETH, THERAPY, TISSUES(BIOLOGY), WOUNDS AND INJURIES, DENTISTRY.

Subject Categories : Biochemistry
      Medicine and Medical Research

Distribution Statement : APPROVED FOR PUBLIC RELEASE