Accession Number : ADA185688

Title :   Phosphoprotein Regulation of Synaptic Reactivity.

Descriptive Note : Final rept. 1 Jul 84-30 Jun 87,

Corporate Author : NORTHWESTERN UNIV EVANSTON IL

Personal Author(s) : Routtenberg, Aryeh

PDF Url : ADA185688

Report Date : 31 Aug 1987

Pagination or Media Count : 7

Abstract : This grant provided equipment for multi-user, multi-tasking minicomputer (VAX 11-750) and a cluster of micro-computers (IBM-XT) to support a DoD funded this research project investigated the regulation of neurobiological responsiveness. High speed digitization of neurophysiological signals and their analysis were performed on-line using IBM-XT installed A-D conversions. In our research program we seek to determine how the phosphorylation state of identified brain proteins regulates inter-synaptic changes in communication between nerve cells, monitored electrophysiologically at the synapse using microelectrodes.

Descriptors :   *NERVE IMPULSES, *NEUROPHYSIOLOGY, *PHOSPHORYLATION, *PROTEINS, *SYNAPSE, ANALOG TO DIGITAL CONVERTERS, BRAIN, ELECTRODES, NERVE CELLS, COMPUTER APPLICATIONS, ELECTROENCEPHALOGRAPHY, NERVE TRANSMISSION, GANGLIA, MINICOMPUTERS, MICROCOMPUTERS, SIGNALS

Subject Categories : Biochemistry
      Anatomy and Physiology

Distribution Statement : APPROVED FOR PUBLIC RELEASE