Accession Number : ADA185914

Title :   Studies of Altered Response to Infection Induced by Severe Injury.

Descriptive Note : Annual rept. 24 Jan 86-23 Jan 87,

Corporate Author : MASSACHUSETTS UNIV MEDICAL SCHOOL WORCESTER DEPT OF SURGERY

Personal Author(s) : Miller, Carol L

PDF Url : ADA185914

Report Date : 01 Mar 1987

Pagination or Media Count : 30

Abstract : The goals of this research are (1) to delineate the role of suppressor T cells and inhibitory monocytes (M0) in mediating the immunosuppression that follows severe injury, (2) to develop and improve assays for assessment of macrophage function, (3) to investigate the relationship between immunosuppression and post-trauma alterations in M0 subsets, and to investigate prophylactic modalities for reversing immunosuppression. We have demonstrated that trauma induced suppressor T cells (Ts) can depress monocyte function and that at least some of the Ts mediate immunosuppression by stimulating monocytes to produce elevated levels of prostaglandin E2 (PGE2). We have concentrated on trying to associate a change in M0 function with a change in M0 phenotype. We have shown that elevation of M0 PGE2 production appears to correlate with the shift toward a M0 subset that can be identified by its expression of a high affinity receptor for the crystalline fragment of Immunoglobulin G (i.e., Fc+). We have demonstrated that there is an increase in the numbers of the Fc+ M0 subset and that this increase correlates both to elevation of PGE2 production and poor clinical outcome.

Descriptors :   *INFECTIOUS DISEASES, *INHIBITION, *SUPPRESSORS, *WOUNDS AND INJURIES, IMMUNOSUPPRESSION, LYMPHOCYTES, MONOCYTES, PHAGOCYTES, RETICULOENDOTHELIAL SYSTEM, RESPONSE(BIOLOGY), HEALING, IMMUNOCHEMISTRY

Subject Categories : Medicine and Medical Research
      Biochemistry

Distribution Statement : APPROVED FOR PUBLIC RELEASE