Accession Number : ADA185957

Title :   Susceptibility of Inbred Syrian Golden Hamsters (Mesocricetus auratus) to Lethal Disease by Lymphocytic Choriomeningitis Virus (42541),

Corporate Author : ARMY MEDICAL RESEARCH INST OF INFECTIOUS DISEASES FORT DETRICK MD

Personal Author(s) : Genovesi, Eugene V. ; Peters, C. J.

Report Date : 1987

Pagination or Media Count : 12

Abstract : An acutely lethal LCMV disease model has been established in the Syrian golden hamster (Mesocricetus auratus) in which lethality and disease are dependent upon both inbred hamster strain the LCMV strain. Young adult inbred, male and female, hamsters were tested for lethal-disease susceptibility by lymphocytic choriomeningitis virus (LCMV)strains, WE or Armstrong (ARM). With WE inocula, PD4 and MHA inbred hamsters were highly susceptible to a wasting disease. LVG and LHC inbred hamsters were intermediate in susceptibility; some of these animals died of wasting illness, and others exhibited minimal disease and survived. CB and LSH hamsters were highly resistant to resistant to any disease by WE. Mean survival times of susceptible hamsters given lethal WE inocula approximated 2.5 weeks and were not dependent on virus does. By 1.5 weeks after WE inoculation wasting disease signs were notable and consisted of lethargy, progressive body weight loss, and diarrhea. The LCMV strain, ARM, was avirulent for all hamster strains, causing neither death nor disease. Hamsters surviving We or ARM inoculation appeared healthy, produced LCMV antibody, and acquired resistance to further lethal WE challenge. Despite hamster-lethality differences, WE and ARM appeared comparably immunogenic for all hamster strains, based on host antibody titers. A number of other differences between the LCMV strains were, however, noted which could be relevant to virus virulence and lethality for hamster hosts. These included guinea pig lethality, temperature sensitivity, and plaque morphology. Reprints

Descriptors :   *HAMSTERS, *MENINGITIS, *VULNERABILITY, ANTIBODIES, BODY WEIGHT, DIARRHEA, GUINEA PIGS, INOCULATION, LETHALITY, MEAN, MODELS, REPRINTS, SENSITIVITY, SURVIVAL(GENERAL), TEMPERATURE, TITRATION, VIRULENCE, VIRUSES, WEIGHT REDUCTION, NEISSERIA MENINGITIDIS.

Subject Categories : Medicine and Medical Research
      Biology

Distribution Statement : APPROVED FOR PUBLIC RELEASE